| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7803129 | European Journal of Medicinal Chemistry | 2011 | 17 Pages |
Abstract
⺠Eighty-eight diverse PPARγ activators were modeled by a combination of pharmacophore and QSAR analyses. ⺠The resulting models were validated by ROC curves and against an external list of compounds. ⺠Optimal models were used as 3D search queries against the NCI list of compounds. ⺠Three hits illustrated nanomolar bioactivation of PPARγ.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Belal O. Al-Najjar, Habibah A. Wahab, Tengku Sifzizul Tengku Muhammad, Alexander Chong Shu-Chien, Nur Adelina Ahmad Noruddin, Mutasem O. Taha,