| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7803164 | European Journal of Medicinal Chemistry | 2011 | 6 Pages |
Abstract
⺠Incorporation of Risp molecules into DG4 was studied. ⺠The best conditions encountered for drug incorporation were: low solvent polarity mixture, pH c.a. 7, room temperature and low ionic strength. ⺠DG4-Risp showed no cell viability reduction at concentrations below 3 Ã 10â2 μM DG4 and 5.1 μM Risp. ⺠No significant hemolysis or morphological changes were observed on red blood cells. ⺠Complex resulted structurally stable for a period of 106 h in buffer.
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Authors
MarÃa Jimena Prieto, Carlos Facundo Temprana, Nahuel Eduardo del RÃo Zabala, Cristian Hernán Marotta, Silvia del Valle Alonso,