| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7803258 | European Journal of Medicinal Chemistry | 2011 | 10 Pages |
Abstract
⺠A series of novel pyrazolo [1,5-a] pyrimidin-7(4H)-ones (PPOs) were synthesized. ⺠A few lead compounds as M channel openers were identified. ⺠Structure-activity relationships of PPOs as M channel openers were established. ⺠Derivatives of PPOs were identified as the novel Kv7/KCNQ channel openers.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as novel Kv7/KCNQ potassium channel activators](/preview/png/7803258.png "First Page Preview: Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as novel Kv7/KCNQ potassium channel activators")
Authors
Jinlong Qi, Fan Zhang, Yi Mi, Yan Fu, Wen Xu, Diqun Zhang, Yibing Wu, Xiaona Du, Qingzhong Jia, Kewei Wang, Hailin Zhang,