| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7803259 | European Journal of Medicinal Chemistry | 2011 | 8 Pages |
Abstract
⺠13 new heterobivalent tacrine derivatives as multi-functional anti-Alzheimer agents were synthesized. ⺠Compounds showed high inhibitory activities for AChE and BuChE. ⺠Compounds interacted at both catalytic active site and peripheral anionic site of AChE. ⺠Some of these compounds exhibited potent antioxidation activity and inhibition of self-induced Aβ aggregation.
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Authors
Wen Luo, Yan-Ping Li, Yan He, Shi-Liang Huang, Ding Li, Lian-Quan Gu, Zhi-Shu Huang,