| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7803284 | European Journal of Medicinal Chemistry | 2011 | 8 Pages |
Abstract
⺠We synthesised a limited series of 5-membered spiroheterocycles-benzopyran as new potential tool to study myocardial-ischemia. ⺠The compounds were evaluated for their cardioprotective activity on cultured H9c2 cardiomyoblasts. ⺠The evaluation of the activity of the most active compound 1a on rat hearts submitted to ischemia/reperfusion cycles showed that mitoKATP channel is involved in cardioprotection. ⺠The structural contraction of the lead compound A does not affect the cardioprotective activity, thus indicating that also the spiro-oxazolidinone scaffold represents a valid structural motif to offer cardioprotection.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Simona Rapposelli, Maria Cristina Breschi, Vincenzo Calderone, Maria Digiacomo, Alma Martelli, Lara Testai, Michael Vanni, Aldo Balsamo,