Discovery of a novel nitroimidazolyl-oxazolidinone hybrid with potent anti Gram-positive activity: Synthesis and antibacterial evaluation

►Antibiotic resistance to Gram-positive pathogens is a major problem in hospitals. ►The oxazolidinones, e.g. linezolid, are a relatively new class of orally active, totally synthetic antibacterial agents active against Gram-positive bacteria. ►The synthesis and in vitro antibacterial activity of novel oxazolidinones containing a nitro-heteroaryl core with potent activity against Gram-positive bacteria have been described.