| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7803314 | European Journal of Medicinal Chemistry | 2011 | 8 Pages |
Abstract
⺠Isoxazolidinyl polycyclic aromatic hydrocarbons act as DNA-intercalator agents. ⺠A fine tuning of these isoxazolidinyl-PAH substrates is relevant to synthesize drugs that could bind DNA specifically to AT or GC nucleobases. ⺠The most potent of them showed an IC50 of 9 mM upon the human lung cancer (A-549) cell and a binding constant, for the intercalation with calf thymus DNA, of 9.6 à 104 Mâ1.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Antonio Rescifina, Ugo Chiacchio, Antonino Corsaro, Anna Piperno, Roberto Romeo,