Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity. part 3

► new 4-aryl-5,6,7,8-tetrahydropyrido[1,2-c]pyrimidine derivatives possessing a 3-(1,2,3,6-tetrahydropyrid-4-yl)-1H-indole group or its 2-methyl derivatives were synthesized. ► new derivatives are considered to have a dual 5-HT1A and SERT activity. ► synthesized ligands possess anticipated agonistic activity toward presynaptic 5-HT1A receptors, while displaying no postsynaptic action. ► degree of saturation pyridine moiety bound to the indole had an influence on KiSERT values for 2-methyl-substituted indole-derivatives.