| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7803322 | European Journal of Medicinal Chemistry | 2011 | 10 Pages |
Abstract
⺠Novel acrylic acids were designed as dual lipoxygenase/cyclooxygenase-1 (LOX/COX-1) inhibitors. ⺠Modifications implicate thienyl, furfuryl, 3,5-ditert-butyl-4-hydroxyphenyl at the 3 position. ⺠Most of them proved to be potent antioxidant and anti-inflammatory agents. ⺠The most active compounds docked successfully into the active site of the inhibited enzymes. ⺠Compounds 1II and 2II inhibit LOX and COX-1 and present anti-inflammatory and antioxidant activities.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Eleni Pontiki, Dimitra Hadjipavlou-Litina, Konstantinos Litinas, Orazio Nicolotti, Angelo Carotti,