Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7803326 | European Journal of Medicinal Chemistry | 2011 | 7 Pages |
Abstract
⺠We have achieved a facile, convenient and high yielding synthesis of 1H-pyrazolo-1,3,4-oxadiazole derivatives having cyclic and acyclic carbohydrate residues through S-glycosidic bond formation. ⺠Pharmacological evaluation of the newly synthesized compounds against 2-cell lines MCF-7 (breast) and HEPG2 (liver) revealed them to possess high or moderate anti-tumor activities. ⺠None of the tested compounds presented any toxicity in doses ranging from 50 to 500 mg kgâ1 of the animal body weight. The lethal doses (LD50) of tested compounds are > 500 mg/kg b. wt.
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Authors
M.A. Abu-Zaied, E.M. El-Telbani, G.H. Elgemeie, G.A.M. Nawwar,