| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7803327 | European Journal of Medicinal Chemistry | 2011 | 5 Pages |
Abstract
⺠Synthesis of methyl 3-amino-6-[(hetero)arylethynyl]thieno[3,2-b]pyridine-2-carboxylates by Sonogashira coupling. ⺠Evaluation of the growth inhibitory activity of the compounds in human tumor cell lines (MCF-7, NCI-H460, A375-C5). ⺠Structure-activity relationships. ⺠Studies of the cell cycle distribution and induction of apoptosis for the most promising compounds.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Synthesis and evaluation of tumor cell growth inhibition of methyl 3-amino-6-[(hetero)arylethynyl]thieno[3,2-b]pyridine-2-carboxylates. Structure-activity relationships, effects on the cell cycle and apoptosis](/preview/png/7803327.png "First Page Preview: Synthesis and evaluation of tumor cell growth inhibition of methyl 3-amino-6-[(hetero)arylethynyl]thieno[3,2-b]pyridine-2-carboxylates. Structure-activity relationships, effects on the cell cycle and apoptosis")
Authors
Maria-João R.P. Queiroz, Ricardo C. Calhelha, LuÃs A. Vale-Silva, Eugénia Pinto, Gabriela M. Almeida, M. Helena Vasconcelos,