| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7803344 | European Journal of Medicinal Chemistry | 2011 | 10 Pages |
Abstract
⺠1,2,5-oxadiazole was proposed as a bioisoster of isoxazole in leflunomide analogues. ⺠Cyano-oximes display weak inhibitory activity on DHODH. ⺠The feeble inhibitory activity of cyano-oximes is amenable to their E configuration. ⺠Oxidation of cyano-oximes to related nitro derivatives increases DHODH inhibition.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Marta Giorgis, Marco Lucio Lolli, Barbara Rolando, Angela Rao, Paolo Tosco, Shilpi Chaurasia, Domenica Marabello, Roberta Fruttero, Alberto Gasco,