| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7803348 | European Journal of Medicinal Chemistry | 2011 | 6 Pages |
Abstract
⺠Reported thiazolylbenzimidazole-4,7-diones are potentially toxic both to tumor cell lines and to normal counterparts. ⺠Novel thiazolylbenzimidazole compounds without quinone moiety were designed and synthesized. ⺠To increase the antitumor activity, efforts were exerted on the structure modification of the thiazole ring. ⺠Most compounds showed good antitumor activities, and compound 11b displayed remarkable in vitro anticancer activity comparable to taxol.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yu Luo, Feng Xiao, Shijing Qian, Wei Lu, Bo Yang,