Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7817961 | Phytochemistry | 2018 | 10 Pages |
Abstract
Chrysin (5,7-dihydroxyflavone), a natural polyphenol, occurs in many plants, honey, and propolis. It appears to have a blend of many pharmacological activities such as anticarcinogenic, pro-apoptotic, antiangiogenic, antimetastatic, immunomodulatory, and antioxidant properties. The molecular mechanisms underlying the pleotropic activities of chrysin are diverse, which involve combinations of cell signaling pathways at multiple levels of various diseases. Chrysin mitigates neurotoxicity, neuroinflammation, and oxidative stress.184
Keywords
DMBAEANMRPCUMSNGFACRDenAGEsSDEforskolinPGE2iNOSLC-MSFskHypoxia-inducible factor-1aCOX-2GSHN-nitrosodiethylamineornithine decarboxylase activitynuclear factor κ-light-chain enhancer of activated B cellsB-CdPCNAPassifloraceaeEEPD-GalNHIF-1AAMPKNRF-2Fe-NTAODCEV71CDDPATCPDGFBZDEnterovirus 71IL-6DOXPPAR-γNF-κBBDEAHRCPIMMPCAPEAMP-activated protein kinaseB(a)PBDNFCVDsd-GalactosamineDMSOexperimental autoimmune neuritisPCAROSAdenosine TriphosphateATPadenylyl cyclaseProliferating Cell Nuclear AntigenAcrylamideprotocatechuic acidgamma amino butyric acidbond dissociation energyHomointerleukin-6highest occupied molecular orbitalBenzo(a)pyrenebenzodiazepineCardiovascular diseaseschronic unpredictable mild stressEMTDoxorubicinMolecular dynamicsDimethyl sulfoxideCAManaplastic thyroid cancerinducible nitric oxide synthasecisplatinCyclooxygenase-2Liquid chromatography mass spectrometryNuclear factor-erythroid 2-related factor 2platelet-derived growth factornerve growth factorBrain-derived neurotrophic factorBioavailabilityferric nitrilotriacetatePharmacological activitiesAdvanced glycation end productsmultidrug resistance proteinProstaglandin E2Molecular dockingCalmodulinChrysinGABAEpithelial–mesenchymal transitionGlutathioneReactive oxygen speciesaryl hydrocarbon receptor
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Renuka Mani, Vijayakumar Natesan,