Scaffolds based on chitosan and collagen with glycosaminoglycans cross-linked by tannic acid

The results showed that the scaffolds based on chitosan, collagen, and glycosaminoglycans cross-linked by tannic acid are not cytotoxic. Scaffolds are stable in aqueous environment and show high swelling behavior. Each material porosity is above 90% which is appropriate for the tissue engineering applications. The mechanical parameters of the scaffolds decrease with increasing immersion time in PBS. SEM images showed the homogeneous scaffold structure with interconnected pores. Due to their stability and biocompatibility, the scaffolds presented here may be easily operated to fit such small bone defects.