Cholesterol concentration effect on the bilayer properties and phase formation of niosome bilayers: A molecular dynamics simulation study

Molecular dynamics simulations were carried out to investigate structural and dynamical properties of niosome bilayers with difference cholesterol concentrations (0-70 mol% Chol). Addition of cholesterols in the niosome bilayer significantly changes the molecular structure and stability. Increasing of cholesterol concentrations causes the area per molecule to increase and bilayer thickness decrease, suggesting that the niosome bilayer is expanded from the gel to the liquid ordered phase.53