Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7843600 | Journal of Molecular Liquids | 2017 | 20 Pages |
Abstract
Pharmacologically important properties of two structurally related biologically active 1,2,4-thiadiazole derivatives were investigated in phosphate buffer and biorelevant media FaSSIF simulating the intestinal fluid. Solubility and distribution coefficients of thiadiazoles were found to be substantially higher in FaSSIF than in blank buffer. On the contrary, permeability coefficients decreased and dissolution rate was not changed in FaSSIF. Mechanism of FaSSIF components action on thiadiazoles behavior was revealed using 1H NMR and UV-spectroscopy.
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Authors
Tatyana Volkova, Ekaterina Chibunova, Oleg Silyukov, Alexey Proshin, Irina Terekhova,