Article ID Journal Published Year Pages File Type
7843600 Journal of Molecular Liquids 2017 20 Pages PDF
Abstract
Pharmacologically important properties of two structurally related biologically active 1,2,4-thiadiazole derivatives were investigated in phosphate buffer and biorelevant media FaSSIF simulating the intestinal fluid. Solubility and distribution coefficients of thiadiazoles were found to be substantially higher in FaSSIF than in blank buffer. On the contrary, permeability coefficients decreased and dissolution rate was not changed in FaSSIF. Mechanism of FaSSIF components action on thiadiazoles behavior was revealed using 1H NMR and UV-spectroscopy.
Related Topics
Physical Sciences and Engineering Chemistry Physical and Theoretical Chemistry
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