| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7860725 | Journal of Controlled Release | 2018 | 24 Pages |
Abstract
Through functional inhibition of acid sphingomyelinase (ASM), cationic amphiphilic drugs (CADs) induce non-lethal lysosomal membrane permeabilization (LMP), enhancing the cytosolic delivery of siRNA and improving target gene knockdown.268
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Authors
Freya Joris, Lynn De Backer, Thijs Van de Vyver, Chiara Bastiancich, Stefaan C. De Smedt, Koen Raemdonck,