| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7861561 | Journal of Controlled Release | 2016 | 43 Pages |
Abstract
The GLCL/siRNA nanoplexes were prepared with electrostatic interaction. After cell internalization, the ssGLCLs were split into two single chain lipid units with the cleavage of disulfide-bridge by abundant reductive glutathione (GSH) in cells, then the resulted monomeric lipid unit exhibited higher membrane fusion and facilitated release of siRNA from lysosomes into cytoplasm, thus the enhanced gene silencing effects on targeted mRNA were obtained.208
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Authors
Xiao-Fei Ma, Jing Sun, Chong Qiu, Yi-Fan Wu, Yi Zheng, Min-Zhi Yu, Xi-Wei Pei, Lin Wei, Yu-Jie Niu, Wen-Hao Pang, Zhen-Jun Yang, Jian-Cheng Wang, Qiang Zhang,