Mitochondrial delivery of Coenzyme Q10via systemic administration using a MITO-Porter prevents ischemia/reperfusion injury in the mouse liver

Article ID	Journal	Published Year	Pages	File Type
7863032	Journal of Controlled Release	2015	10 Pages	PDF

Keywords

EPC NBD-DOPE 3H-cholesterylhexadecyl ether PBS (−)COX IV MITO-Porter I/R injury CoQ10 ALT MIB CLSM GAPDH HEPES 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid DiI ROS AST Aspartate aminotransferase Ischemia/reperfusion injury Alanine aminotransferase sphingomyelin In vivo delivery Mitochondrial delivery egg yolk phosphatidylcholine cytochrome c oxidase subunit IV Phosphate-buffered saline Mitochondria confocal laser scanning microscopy DOPE Channel Coenzyme Q10 glyceraldehyde 3-phosphate dehydrogenase Reactive oxygen species

Related Topics

Physical Sciences and Engineering Materials Science Biomaterials

Mitochondrial delivery of Coenzyme Q10via systemic administration using a MITO-Porter prevents ischemia/reperfusion injury in the mouse liver

Authors

Yuma Yamada, Kohei Nakamura, Jiro Abe, Mamoru Hyodo, Sanae Haga, Michitaka Ozaki, Hideyoshi Harashima,