Agile delivery of protein therapeutics to CNS

Article ID	Journal	Published Year	Pages	File Type
7864593	Journal of Controlled Release	2014	27 Pages	PDF

Abstract

Brain delivery of proteins has been improved through several chemical modification strategies including cationization, fusing with cell-penetrating peptides (CPPs), fatty acylation, and conjugation with brain targeting ligands or block copolymers.170

Keywords

PEI EGFR PLGA EGF CHOL CMC RAP PCL CED TFR POX ASA BIC GFAP RDP PLA bFGF GSH Aβ HRP EPO KLH FGF BMM PPO DPP-IV butyrylcholinesterase IGF-I EAE NGF intracerebroventricular GDNF MCAO i.c.v.PACAP TPGS GLP-1 M6P DIO PGP i.v.NVU NT-3 s.c.LRP1 apoB α-L-iduronidase MtF MPS II MPS I TNFR VLDL PPG BChE BMECs Oxyntomodulin INSR Mucopolysaccharidosis II I2S LSDs HPMA Poly(2-oxazoline)s Arylsulfatase A TBI Block ionomer complexes PBCA FDA Poly(butylcyanoacrylate)HIV-1-associated dementia SopE Aerosol OT INB OXM AUC BDNF CPPs ECs P-glycoprotein Traumatic brain injury amyloid β enzyme replacement therapy experimental autoimmune encephalomyelitis Apoe Apolipoprotein B apolipoprotein E i.t.tight junctions lysosomal storage disorders Iduronate-2-sulfatase erythropoietin amyotrophic lateral sclerosis insulin-like growth factor I intrathecal Intranasal Alzheimer's disease ALS Parkinson's disease TAT Convection-enhanced delivery Brain delivery Protein delivery trans-activating transcriptional activator position emission tomography SCAR Shh Intravenous HAD Protein therapeutics CNS Dioleoyl phosphatidylethanolamine dipeptidyl peptidase IV subcutaneous Food and Drug Administration SOD BBB Blood–brain barrier brain microvessel endothelial cells Superoxide dismutase central nervous system sonic hedgehog epidermal growth factor Intramuscular critical micelle concentration Pharmacokinetics nerve growth factor fibroblast growth factor basic fibroblast growth factor Brain-derived neurotrophic factor glial cell-derived neurotrophic factor phosphatidylcholine Phosphatidylserine extracellular space very-low-density lipoprotein Low-density lipoprotein LDL mannose 6-phosphate Bone-Marrow Derived Macrophages Cerebrospinal fluid CSF Middle cerebral artery occlusion model Administration route Melanotransferrin i.m.area under the curve Multiple sclerosis Mucopolysaccharidosis I neurotrophin-3 ERT neurovascular unit HIV-1 human immunodeficiency virus 1 PET Horseradish peroxidase receptor associated protein Poly(2-ethyl-2-oxazoline)Poly(2-methyl-2-oxazoline)Poly(propylene oxide)Poly(ε-caprolactone)poly(ethylene oxide)Poly(ethylene glycol)Poly(ethyleneimine)Polylactic acid Polypropylene glycol pituitary adenylate cyclase activating polypeptide PEG glucagon-like peptide 1 cell-penetrating peptides DOPE PEO diet-induced obese reduced glutathione cholesterol keyhole limpet hemocyanin i.n.EGF receptor transferrin receptor insulin receptor