| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7865546 | Materials Science and Engineering: C | 2018 | 11 Pages |
Abstract
Obesity as a dominant problem in developed countries which is known to be basic step of so many diseases is subjected to find a solution for in this work. Curcumin containing polyvinyl alcohol-gelatin nanofibers which ranging from 200 to 250â¯nm in diameter as a transdermal drug delivery system for declining volume of subcutaneous adipose tissue is investigated here. Morphology and synthesis method of nanofibers is designed and optimized by statistical software and a totally uniform and reproducible method of synthesis is used for preparation of a transdermal patch. Effectiveness of delivery system in transport of drug through skin is confirmed by side by side arrangement transdermal diffusion cells. This transdermal patch used for animal test showed 4 to 7% decrease in total amount of adipose tissue estimated by whole body magnetic resonance imaging technique.
Related Topics
Physical Sciences and Engineering
Materials Science
Biomaterials
Authors
Amir reza Ariamoghaddam, Bahman Ebrahimi-Hosseinzadeh, Ashrafalsadat Hatamian-Zarmi, Razi Sahraeian,