Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7866311 | Materials Science and Engineering: C | 2018 | 27 Pages |
Abstract
In recent years, gelatin-based composites hydrogels have been intensively investigated because of their inherent bioactivity, biocompatibility and biodegradability. Herein, we fabricated photocrosslinkable biomimetic composites hydrogels from bioactive glass (BG) and gelatin methacryloyl (GelMA) by a sequential physical and chemical crosslinking (gelationâ¯+â¯UV) approach. The results showed that the compressive modulus of composites hydrogels increased significantly through the sequential crosslinking approach. The addition of BG resulted in a significant increase in physiological stability and apatite-forming ability. In vitro data indicated that BG/GelMA composites hydrogels promoted cell attachment, proliferation and differentiation. Overall, the BG/GelMA composites hydrogels combined the advantages of good biocompatibility and bioactivity, and had potential applications in bone regeneration.
Related Topics
Physical Sciences and Engineering
Materials Science
Biomaterials
Authors
Jiafu Zheng, Fujian Zhao, Wen Zhang, Yunfei Mo, Lei Zeng, Xian Li, Xiaofeng Chen,