| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7869708 | Materials Science and Engineering: C | 2015 | 7 Pages |
Abstract
Four different phase compositions of calcium phosphate (CaP) particles were prepared via a solution combustion method. X-ray diffraction (XRD) and Rietveld analysis results revealed that the variations in the nominal Ca/P (molar) ratios were found to provide a favorable control in the different proportions of CaP materials. Bovine serum albumin (BSA) was used as a model protein to study the loading and release behavior. The release profile indicated that the BSA release rates depended on the phase compositions of the CaP particles, and showed an order of TCP-BSAÂ >Â BCP-1-BSAÂ >Â BCP-2-BSAÂ >Â HA-BSA. The results suggested that the BSA protein release rate can be controlled by varying the phase compositions of CaP carriers. Moreover, the release process involved two stages: firstly surface diffusion via ion exchange and secondly intraparticle diffusion.
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Authors
Junfeng Zhao, Junjie Zhao, Yu Qian, Xiali Zhang, Feifei Zhou, Hong Zhang, Hongbin Lu, JianHua Chen, XuHong Wang, Wencong Yu,