Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7869892 | Materials Science and Engineering: C | 2015 | 7 Pages |
Abstract
Poly(lactic acid) (PLA) is a kind of non-toxic biological materials with excellent absorbability, biocompatibility and biodegradability, which can be used for drug release, tissue engineering and surgical treatment applications. In this study, we prepared chitosan modified PLA nanoparticles as carriers for encapsulation of docetaxel by anti-solvent precipitation method. The morphology, particle size, zeta potential and composition of the PLA/chitosan were characterized by SEM, DLS, FTIR and XPS. As-prepared PLA/chitosan particles exhibited average size of 250Â nm and showed very narrow distribution with polydispersity index of 0.098. Their large surface charge-ability was confirmed by zeta potential value of 53.9Â mV. Docetaxel was released from PLA/chitosan nanoparticles with 40% initial burst release in 5Â h and 70% cumulative release within 24Â h, while from PLA nanoparticles 65% of docetaxel was released in 5Â h. In vitro drug release study demonstrated that PLA/chitosan nanoparticles prolonged drug release and decreased the burst release over the unmodified PLA nanoparticles. These results illustrated high potential of chitosan modified PLA nanoparticles for usage as anticancer drug carriers.
Related Topics
Physical Sciences and Engineering
Materials Science
Biomaterials
Authors
Wenlong Wang, Shu Chen, Liang Zhang, Xi Wu, Jiexin Wang, Jian-Feng Chen, Yuan Le,