Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7870110 | Materials Science and Engineering: C | 2014 | 6 Pages |
Abstract
This study aims to generate a bactericidal agent releasing surface via nanotube layer on titanium metal and to investigate how aspect ratio of nanotubes affects drug elution time and cell proliferation. Titania nanotube layers were generated on metal surfaces by anodic oxidation at various voltage and time parameters. Gentamicin loading was carried out via simple pipetting and the samples were tested against S. aureus for the efficacy of the applied modification. Drug releasing time and cell proliferation were also tested in vitro. Titania nanotube layers with varying diameters and lengths were prepared after anodization and anodizing duration was found as the most effective parameter for amount of loaded drug and drug releasing time. Drug elution lasted up to 4Â days after anodizing for 80Â min of the samples, whereas release completed in 24Â h when the samples were anodized for 20Â min. All processed samples had bactericidal properties against S. aureus organism except unmodified titanium, which was also subjected to drug incorporation step. The anodization also enhanced water wettability and cell adhesion results. Anodic oxidation is an effective surface modification to enhance tissue-implant interactions and also resultant titania layer can act as a drug reservoir for the release of bactericidal agents. The use of implants as local drug eluting devices is promising but further in vivo testing is required.
Related Topics
Physical Sciences and Engineering
Materials Science
Biomaterials
Authors
Nazlı ÃalıÅkan, Cem Bayram, Ebru Erdal, Zeynep KarahaliloÄlu, Emir Baki DenkbaÅ,