Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7931005 | Optics Communications | 2014 | 5 Pages |
Abstract
We investigated the suitability of the semi-infinite model of the diffusion equation when using diffuse optical imaging (DOI) to image thin tissues with double boundaries. Both diffuse approximation and Monte Carlo methods were applied to simulate light propagation in the thin tissue model with variable optical parameters and tissue thicknesses. A threshold value of the tissue thickness was defined as the minimum thickness in which the semi-infinite model exhibits the same reflected intensity as that from the double-boundary model and was generated as the final result. In contrast to our initial hypothesis that all optical properties would affect the threshold thickness, our results show that only absorption coefficient is the dominant parameter and the others are negligible. The threshold thickness decreases from 1Â cm to 4Â mm as the absorption coefficient grows from 0.01Â mmâ1 to 0.2Â mmâ1. A look-up curve was derived to guide the selection of the appropriate model during the optical diagnosis of thin tissue cancers. These results are useful in guiding the development of the endoscopic DOI for esophageal, cervical and colorectal cancers, among others.
Related Topics
Physical Sciences and Engineering
Materials Science
Electronic, Optical and Magnetic Materials
Authors
Yunyao Zhang, Jingping Zhu, Weiwen Cui, Wei Nie, Jie Li, Zhenghong Xu,