Cell adhesion behavior of poly(ε-caprolactone)/poly(L-lactic acid) nanofibers scaffold

Biodegradable nanofiberous tubes are being investigated and developed for nerve tissue regeneration. The poly (ε-caprolactone) and poly (L-lactic acid) offer competitive candidacy due to higher stability by former and better biodegradability of the latter. Exploiting these characteristics of both the polymers, we present our study on generation of nanofiber tubes from pure PCL, pure PLLA and their blends (PCL/PLLA). The nanofibers were electrospun and collected on 2 cm diameter rotating collector. The samples were analyzed for cell adhesion, tensile strength, homogeneity, chemical analysis by FTIR. The results show comparatively enhanced cell adhesion in PLLA samples and blends with higher PLLA proportion. Contrary, samples with higher PCL proportion depicted better tensile strength. FTIR results demonstrated PCL and PLLA characteristic peaks in their blends. The results confirm suitability of PCL/PLLA nanofiberous tubes for nerve tissue regeneration and tissue growth.