Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8017605 | Materials Letters | 2016 | 13 Pages |
Abstract
We constructed a novel WO3 interlayered Fe3O4@WO3@mSiO2-APTES core-shell structured drug nanocarrier to investigate loading and controllable release properties of etoposide (VP16). This nanocomposite composed of mesoporous silica (mSiO2) shell with magnetic Fe3O4 core, WO3 interlayer. They possesses high surface area of 234.5Â m2/g, provides large accessible pore volume of 0.14Â cm3/g for adsorption of drug molecules, high magnetization saturation value of 40.54Â emu/g for drug targeting under foreign magnetic fields, relatively higher reflection loss of â22.75Â dB for controlled release by microwave-triggered which was caused by WO3 interlayer. The VP16 release of over 85.69% under microwave discontinuous irradiation outclasses the 15.88% within 600Â min only stirring release. This multifunctional material shows good performance for targeting delivery and WO3 microwave controlled release of anticancer drugs based on all the properties they possess.
Related Topics
Physical Sciences and Engineering
Materials Science
Nanotechnology
Authors
Weiwei Zhao, Bin Cui, Hongjin Qiu, Ping Chen, Yaoyu Wang,