| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8018636 | Materials Letters | 2015 | 4 Pages |
Abstract
A thermosensitive artificial skin composed of gelatin-chitosan (Gel-CS) scaffold as dermis and poly(N-isopropyl acrylamide) (PNIPAAm) grafted microporous polyurethane (PU) membrane as epidermis bound together by gelatin was prepared, and its morphological structure, water vapor permeability rate (WVPR) and in vivo biological properties were investigated. The results showed that the as-prepared artificial skin showed a “Sandwich” structure and its WVPR was 804Â g/m2Â day, close to those from commercial skin dressings (426-2047Â g/m2Â day). The in vivo tests indicated that the “Sandwich” artificial skin could effectively accelerate wound closure in a rat model with full-thickness skin loss and the epidermis could easily peel off after wound healing.
Related Topics
Physical Sciences and Engineering
Materials Science
Nanotechnology
Authors
Ying Tu, Mingbing Zhou, Zhijun Guo, Yubao Li, Yi Hou, Danqing Wang, Li Zhang,