Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8020688 | Materials Letters | 2014 | 4 Pages |
Abstract
Highly hierarchical pore structure (macro-micro-nano) for biomimetic nanofibrous scaffolds could efficiently enhance cell infiltration and tissue formation. However, it is difficult to prepare these structures by using traditional electrostatic spinning techniques. Here, we report a facile method to fabricate polycaprolactone (PCL) nanofibrous scaffolds with multi-scale pore structure by simple phase separation. By employing water-dioxane as solvents and tris spheres as macropore template, PCL nanofibrous scaffolds with pores 300-800 µm, 1-10 µm and 100-1000 nm in diameter can be facilely produced. All scaffolds possess controlled nanofibrous morphology and porosity (90-98%). This scaffold may provide promising applications in tissue engineering and drug delivery.
Related Topics
Physical Sciences and Engineering
Materials Science
Nanotechnology
Authors
Yuzhang Du, Xiaofeng Chen, Young Hag Koh, Bo Lei,