Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8021176 | Materials Letters | 2014 | 4 Pages |
Abstract
Monodisperse magnetic microspheres with biodegradability and biocompatibility were successfully prepared using a T-shaped microchannel reactor instead of the traditional three-necked flask equipped with the mechanical stirrer. Solvothermal was adopted to produce hydrophilic ferriferrous oxide (Fe3O4) nanoparticles with high magnetic responsiveness, which was subsequently emulsified with a dichloromethane solution of polylactic acid (PLA) in the presence of a gelatin stabilizer. This water-in-oil (W/O) emulsion and an additional aqueous phase, namely an aqueous polyvinyl alcohol (PVA) solution, were injected into the T-shaped microchannel reactor and converged at the joint to yield a W/O/W composite emulsion. Evaporation of the solvent in the microchannel gave rise to the target magnetic microspheres. The results show that the magnetic microspheres have a uniform particle size and good magnetic responsiveness, indicating their potential use in targeted drug delivery for cancer treatment and thermotherapy.
Related Topics
Physical Sciences and Engineering
Materials Science
Nanotechnology
Authors
Peng Liu, Yi Zhong, Yan Luo,