The potential of hyaluronic acid in immunoprotection and immunomodulation: Chemistry, processing and function

Article ID	Journal	Published Year	Pages	File Type
8022956	Progress in Materials Science	2018	68 Pages	PDF

Abstract

Hyaluronic acid (HA) is a glycosaminoglycan that is found in extracellular tissue in many parts of the body. It is a material of increasing importance to biomaterials science and is finding applications in diverse areas ranging from tissue culture scaffolds to cosmetic materials. This paper reviews the recent research on the role of HA as a immunoprotective and immunomodulatory biomaterial and the importance of HA in combating immune related diseases such as type 1 diabetes, cancer, and autoimmunity. The chemical modifications and processing methods employed to produce HA-modified materials are discussed, thus giving a better understanding of the structure-function-property relationships that influence immunomodulation, immunoprotection and stability. The article concludes with a discussion on the latest progress in HA materials science which is enabling the realisation of new therapies such as vaccine delivery, immunotherapy, cell encapsulation and transplantation.

Keywords

ECM HEC PVA PLGA MMP PBS LPS CCL2 DAMPs EDC DVS hMSCs PLA MCF-7 HRP BCG MWCO LbL hESCs PAMPs TGFβ CD44 ERK IBD HUVEC LMW SIS HMW GDF GAG DCs PrP GPi NSCs NHS LAP BSS NPC HOBt IPN PAI-1 PLL HAS T1DM Tregs proteoglycans PRRs DMPA HDAC3 PKCδ N-hydroxysuccinimide BDDE C-C Motif Chemokine Ligand 2 hADSCs AEMA 2,2-Dimethoxy-2-phenylacetophenone Crosslinking degree Hyaluronan-mediated motility receptor TSG-6 APMA 1-hydroxybenzotriazole Bacillus Calmette-Guérin G″G′ROS TLRs Rheumatoid arthritis HLA Osteoarthritis Hyaluronic acid damage-associated molecular patterns pathogen-associated molecular patterns Cell encapsulation Vascularization Immunoprotection interleukin Inflammatory bowel disease Transforming growth factor β Immunomodulation Hare cluster of differentiation 44 Double network type 1 diabetes mellitus Rhamm Small Intestine Submucosa Human umbilical vein endothelial cells human embryonic stem cells human adipose-derived stem cells human mesenchymal stem cells Dendritic cells Neural stem cells Regulatory T cells Interpenetrating networks Growth differentiation factor Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)Layer-by-layer lipopolysaccharide Extracellular matrix Matrix metalloprotease Methacrylate MHC major histocompatibility complex balanced salt solution SEM loss modulus Storage modulus MeS Genome-wide association studies GWAS Plasminogen activator inhibitor-1 Multiple sclerosis Scanning electron microscopy R-ratio Swelling ratio Nitric oxide Hyal Hyaluronan synthase Hyaluronidase hydroxyethyl cellulose histone deacetylase 3 Molecular weight high molecular weight low molecular weight PAMAM Horseradish peroxide Protein kinase C platelet-rich plasma poly(lactic-co-glycolic acid)Poly(lactide)Polyamidoamine polyethylene glycol polyvinyl alcohol Poly-l-lysine PEG molecular weight cut-off extracellular signal-regulated kinase Glycosaminoglycan Reactive oxygen species pattern recognition receptors