Gamma radiative fabrication of semi interpenetrating network film: Optimization, characterization and investigation as colon, intestine specific drug release device

Presented work was fabrication of colon and intestine specific drugs release device using gamma radiations as initiators. Semi-interpenetrating network (Semi-IPN) film was castoff as drug delivery device to investigate release profile of diethyl carbamazine citrate and amoxicillin in 9.2, 7.0 and 2.2 pH media. Optimized reaction parameters for semi-IPN film were: gamma dose 2.5 kGy/h; solvent 25 ml; AA 4.6 mol/L; MBA 5.1 × 10−3 mol/L and pH 9.0. Sample was characterized by X-RD; SEM; FT-IR and TGA studies. Semi-IPN film was thermally more stable than backbone showing 6400% water uptake efficacy. Sample degraded upto 80.3% and 81.7% at a degradation rate of 1.147(mg/min) and 1.167(mg/min) in vermi-composting and bio-composting degradations, respectively. Release behavior of diethyl carbamazine citrate was found to be non-Fickian in 9.2, 7.0 pH and Fickian in 2.2 pH solutions. In amoxicillin case II diffusion was found in 9.2 pH, non-Fickian in 7.0 and 2.2 pH solutions. Both drugs showed their maximum release in 9.2 pH media with higher values of Di than DL, thus can be used as colon and intestine specific release device where, drug released rate should be fast in the beginning followed by sustain release.