Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8045784 | Applied Clay Science | 2018 | 7 Pages |
Abstract
In this work, a study of Lecithin-heparin intercalated in montmorillonite was performed in order to synthesize an antithrombogenic hybrid. The hybrid of montmorillonite (Mt)/Lecithin-heparin (LEC-HEP) was synthesized by the intercalation method under mechanical stirring. The composite was characterized by X-ray diffraction (XRD) analysis, X-ray fluorescence (XRF) and C, H, and N elemental analyses, zeta potentials, Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA) techniques. The d001-value was increased by LEC-HEP intercalation. Fourier transform infrared spectroscopy also confirmed the intercalation of Lecithin-heparin into Mt interlayer space. In vitro release study of the antithrombogenic drug-Mt intercalates in phosphate buffer saline (pHâ¯7.4) media at 37â¯Â°C was investigated. The heparin showed an initial burst effect for 24â¯h and then continuously released for 30â¯d. In-vitro blood compatibility of the Mt/LEC-HEP was carried out via hemolysis assay. The Mt/LEC-HEP exhibited hemolysis below 5% which is permissible for biomaterials. These modified materials have the potential for being used as blood contact materials.
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Authors
Na Meng, Xiaohong Chu, Man Qing Ge, Ming Zhang, Baohong Sun, Yu-Tian Su, Ning-Lin Zhou,