Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8046241 | Applied Clay Science | 2018 | 10 Pages |
Abstract
Halloysite nanotubes functionalized with polyamidoamine dendrimer were prepared and characterized. The material studied was applied as a carrier of three model therapeutic compounds - chlorogenic acid, ibuprofen and salicylic acid. It showed higher adsorption capacity for the drugs studied (123.16Â mg/g for chlorogenic acid; 182.72Â mg/g for ibuprofen; 39.52Â mg/g for salicylic acid) compared to raw halloysite and 3-aminopropyltrimethoxysilane functionalized - halloysite nanotubes. The experimental adsorption data fits the Langmuir model. As a result of surface functionalization of halloysite with the dendrimer, the release rate of chlorogenic and salicylic acid decreased, while the release profile of ibuprofen was similar to that of 3-aminopropyltrimethoxysilane functionalized nanotubes. The release kinetics of chlorogenic acid and salicylic acid followed Higuchi model and the release exponents indicated a Fickian diffusion mechanism. The release mode of ibuprofen followed the first order kinetics and the mechanism was described as non-Fickian (anomalous) transport. The in vivo toxicity studies showed that the dendrimer -functionalized halloysite had no effect on the living organisms used in the bioassays.
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Authors
Joanna Kurczewska, MichaÅ CegÅowski, Beata Messyasz, Grzegorz Schroeder,