Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8048541 | Manufacturing Letters | 2018 | 5 Pages |
Abstract
We fabricated vertically aligned polyaniline (PANI) nanowire arrays on flat-end AFM tips via template-free methods. 4-Aminothiophenol was used for tailoring the nucleation size, chain propagation and orientation of the PANI nanowires. The microscopy characterization indicated that diameter was centered at a mean of 33.7â¯nm with a standard deviation of 6.5â¯nm, and length was centered at a mean of 50.3â¯nm with a standard deviation of 7.6â¯nm. PANI nanowire arrays are non-toxic, low-cost, and tunable, and thus PANI nanowire-grown tips could perfectly simulate different nanosurfaces. Via the force spectroscopy, we demonstrate the feasibility in real-time quantifying the nanostructure-cell interactions at the single cell level with high reliability and accuracy. This work will enable a new tool in precisely quantifying the interactions of single living cells and nanosurface, and thus opens a new door to understand how single living cells sense and respond to the specific nanostructures.
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Authors
Biran Wang, Liming Wang, Xi Li, Yuchen Liu, Zimeng Zhang, Erik Hedrick, Stephen Safe, Jingjing Qiu, Guohui Lu, Shiren Wang,