Finite Element simulation of buckling-induced vein tortuosity and influence of the wall constitutive properties

•We test the hypothesis that vein tortuosity results from wall mechanical degradation.•Finite Element model of venous tortuosity onset under internal pressure.•Identification of anisotropic mechanical behavior from previous inflation test data.•Alteration of the wall mechanical behavior has significant effects on tortuosity.

The mechanisms giving rise to vein tortuosity, which is often associated with varicosis, are poorly understood. Recent works suggest that significant biological changes in the wall of varicose veins may precede the mechanical aspects of the disease. To test the hypothesis of tortuosity being a consequence of these changes, a Finite Element model was developed based on previous experimental work on vein buckling. The model was then used to evaluate the effect of alterations of the mechanical behavior of the wall on tortuosity onset and severity. The results showed that increasing anisotropy toward the circumferential direction promotes tortuosity. An increase in wall stiffness tends to decrease the level of tortuosity but interestingly, if the vein segment is little or not pre-stretched such increase will not prevent, or it will even promote, the onset of tortuosity. These results provide additional arguments supporting the hypothesis of tortuosity being the consequence of biologically-induced changes in the varicose vein wall. Based on a 3D model of the leg and in vivo identification of the material properties of varicose veins, a clinical validation of these findings is being developed.

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