Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
811135 | Journal of the Mechanical Behavior of Biomedical Materials | 2012 | 9 Pages |
Abstract
The elastic modulus of an oral cancer cell line UM1 is investigated by nanoindentation in an atomic force microscope with a flat-ended tip. The commonly used Hertzian method gives apparent elastic modulus which increases with the loading rate, indicating strong effects of viscoelasticity. On the contrary, a rate-jump method developed for viscoelastic materials gives elastic modulus values which are independent of the rate-jump magnitude. The results show that the rate-jump method can be used as a standard protocol for measuring elastic stiffness of living cells, since the measured values are intrinsic properties of the cells.
Related Topics
Physical Sciences and Engineering
Engineering
Biomedical Engineering
Authors
Z.L. Zhou, A.H.W. Ngan, B. Tang, A.X. Wang,