Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8131259 | Ultrasound in Medicine & Biology | 2018 | 11 Pages |
Abstract
Enzyme-induced articular cartilage degeneration resembling osteoarthritis was evaluated using a newly defined acoustic parameter, the “averaged magnitude ratio” (AMR), which has been suggested as an indicator of articular cartilage degeneration. In vitro experiments were conducted on porcine cartilage samples digested with trypsin for 2âh (nâ=â10) and 4âh (nâ=â13) and healthy control samples (nâ=â13). AMR was determined with 15- and 25-MHz ultrasound, and the integrated reflection coefficient (IRC) and apparent integrated backscattering coefficient (AIB) were also calculated for comparison. The Young's modulus of superficial cartilage was measured using atomic force microscopy. Performance of the AMR differs between 15 and 25âMHz, possibly because of frequency-related attenuation and resolution of ultrasound. At the proper settings, AMR exhibited a competence similar to that of IRC and AIB in detecting cartilage degeneration and could also detect differences in deeper positions. Furthermore, AMR has the advantages of being easy to measure and requiring no reference material.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Acoustics and Ultrasonics
Authors
Jingchen Zhang, Liying Xiao, Lingying Tong, Chao Wan, Zhixiu Hao,