Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8131483 | Ultrasound in Medicine & Biology | 2017 | 11 Pages |
Abstract
This study aimed to evaluate the role of echocardiography-based strain analysis in the early diagnosis and guidance for management of dilated cardiomyopathy (DCM). Muscular dystrophy mice (which spontaneously develop DCM) and control (C57 BL/6Â J) mice were sequentially evaluated by ultrasound biomicroscopy, conventional left ventricle (LV) measurement, two-dimensional (2-D) strain analysis and myocardial histologic analysis for 12 consecutive months. Significant alternation of LV remodeling and dysfunction could be detected by conventional echocardiography after 9Â mo, by strain analysis after 5Â mo and by histologic analysis after 4Â mo. The global longitudinal systolic peak strain (PK) was the most sensitive strain marker for early detection of myocardial structural abnormality in the subclinical stage. Moreover, losartan administration before the PK decrease was associated with significantly preserved LV function. These results suggest that myocardial strain analysis (particularly longitudinal PK) is sensitive for the early detection of LV dysfunction in mice with dilated cardiomyopathy.
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Authors
Minjuan Zheng, Feng Pan, Ying Liu, Zhenzhou Li, Xiaodong Zhou, Xin Meng, Liwen Liu, Shuping Ge,