Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8131554 | Ultrasound in Medicine & Biology | 2014 | 11 Pages |
Abstract
The purpose of this study was to measure changes in cardiac function as cardiomyopathy progresses in a mouse model of Duchenne muscular dystrophy using 3-D ECG-gated echocardiography. This study is the first to correlate cardiac volumes acquired using 3-D echocardiography with those acquired using retrospectively gated micro-computed tomography (CT). Both were further compared with standard M-mode echocardiography and histologic analyses. We found that although each modality measures a decrease in cardiac function as disease progresses in mdx/utrn-/- mice (n = 5) compared with healthy C57BL/6 mice (n = 8), 3-D echocardiography has higher agreement with gold-standard measurements acquired by gated micro-CT, with little standard deviation between measurements. M-Mode echocardiography measurements, in comparison, exhibit considerably greater variability and user bias. Given the radiation dose associated with micro-CT and the geometric assumptions made in M-mode echocardiography to calculate ventricular volume, we suggest that use of 3-D echocardiography has important advantages that may allow for the measurement of early disease changes that occur before overt cardiomyopathy.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Acoustics and Ultrasonics
Authors
Andrew B. Bondoc, Sarah Detombe, Joy Dunmore-Buyze, Kelly M. Gutpell, Linshan Liu, Amanda Kaszuba, Seongryoung Han, Rebecca McGirr, Jennifer Hadway, Maria Drangova, Lisa M. Hoffman,