Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8149507 | Journal of Crystal Growth | 2016 | 7 Pages |
Abstract
This work highlights the effect of the stirring, the temperature and the supersaturation on the cooling crystallization of l-Glutamic acid (LGlu) polymorphs. First, solubility measurements of the metastable polymorph α and the stable polymorph β were performed. Then, crystallization experiments were carried out in stirred vessel and in stagnant cell. All these experiments were monitored by in situ devices. The effect of the temperature on the LGlu polymorphs was found to be more relevant than the supersaturation in the stirred crystallizer. In the stagnant cell, only the stable form β crystallized regardless of the operating conditions. Moreover, an unexpected and new habit of the β form was discovered and confirmed. These results suggest that the temperature and the stirring can strongly affect the nucleation and the growth kinetics of polymorphic forms.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Condensed Matter Physics
Authors
Yousra Tahri, Emilie Gagnière, Elodie Chabanon, Tijani Bounahmidi, Denis Mangin,