Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8153541 | Journal of Magnetism and Magnetic Materials | 2018 | 5 Pages |
Abstract
In the broad research of the GMR bio-sensing technology, it is vital to explore appropriate magnetic labels and its influences on the detection signal. In this work, four kinds of ferrite particles of γ-Fe2O3, CoFe2O4, NiFe2O4 and NiZnFe2O4 were prepared through calcining the Dimethyl Formamide (DMF) solution of the transition metal nitrates [Fe(NO3)3 and X(NO3)2, Xâ¯=â¯Co, Ni, Zn] to study the effect of magnetic properties on detection signals using a DC in-plane measuring method. It was revealed that for four particles, the output voltage differences |ÎV| between with and without magnetic particles exhibit log-linear functions of the particles concentrations x in the range from 0.1 to 10â¯ng/mL. A very low limitation of detection (LOD) of 0.1â¯ng/mL for all the samples was obtained, which is two orders smaller than that in the previous work. Moreover, the change of output voltage difference at the LOD (|ÎVlim|) is proportional to the magnetization at bias field (bias magnetization, Mbias), which indicates that larger Mbias leads to a lower LOD. This work provides a useful guidance in selecting or preparing magnetic labels to enhance the sensitivity of GMR biosensors.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Condensed Matter Physics
Authors
Yang Zhang, Jie Xu, Derang Cao, Qiang Li, Guoxia Zhao, Nian X. Sun, Shandong Li,