Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8155445 | Journal of Magnetism and Magnetic Materials | 2016 | 12 Pages |
Abstract
In this study, manganese ferrite/graphene oxide (MnFe2O4/GO) nanocomposites as controlled targeted drug delivery were prepared by a facile sonochemical method. It was found that GO nanosheets were fully exfoliated and decorated with MnFe2O4 nanoparticles having diameters of 5-13 nm. The field-dependent magnetization curve indicated superparamagnetic behavior of the obtained MnFe2O4/GO with saturation magnetization of 34.9 emu/g at room temperature. The in vitro cytotoxicity testing exhibited negligible cytotoxicity of as-prepared MnFe2O4/GO even at the concentration as high as 150 μg/mL. Doxorubicin hydrochloride (DOX) as an anti-tumor model drug was utilized to explore the application potential of MnFe2O4/GO for controlled drug delivery. The drug loading capacity of this nanocarrier was as high as 0.97 mg/mg and the drug release behavior showed a sustained and pH-responsive way.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Condensed Matter Physics
Authors
Guangshuo Wang, Yingying Ma, Lina Zhang, Jingbo Mu, Zhixiao Zhang, Xiaoliang Zhang, Hongwei Che, Yongmei Bai, Junxian Hou,