Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8155996 | Journal of Magnetism and Magnetic Materials | 2015 | 7 Pages |
Abstract
We report evidence for the possible application of chitosan-coated nickel-ferrite (NiFe2O4) nanoparticles as both T1 and T2 contrast agents in magnetic resonance imaging (MRI). The coating of nickel-ferrite nanoparticles with chitosan was performed simultaneously with the synthesis of the nickel-ferrite nanoparticles by a chemical co-precipitation method. The coated nanoparticles were cylindrical in shape with an average length of 17 nm and an average width of 4.4 nm. The bonding of chitosan onto the ferrite nanoparticles was confirmed by Fourier transform infrared spectroscopy. The T1 and T2 relaxivities were 0.858±0.04 and 1.71±0.03 mMâ1 sâ1, respectively. In animal experimentation, both a 25% signal enhancement in the T1-weighted mage and a 71% signal loss in the T2-weighted image were observed. This demonstrated that chitosan-coated nickel-ferrite nanoparticles are suitable as both T1 and T2 contrast agents in MRI. We note that the applicability of our nanoparticles as both T1 and T2 contrast agents is due to their cylindrical shape, which gives rise to both inner and outer sphere processes of nanoparticles.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Condensed Matter Physics
Authors
Tanveer Ahmad, Hongsub Bae, Yousaf Iqbal, Ilsu Rhee, Sungwook Hong, Yongmin Chang, Jaejun Lee, Derac Sohn,