Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
816550 | Beni-Suef University Journal of Basic and Applied Sciences | 2016 | 7 Pages |
Abstract
A series of new 2-(substitutedphenoxy)-N-[(aryl)methylidene]acetohydrazide analogues (8a-n) were synthesized in search of potential therapeutics for leishmaniasis. All the compounds were characterized by infrared (IR), nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. The compounds were further evaluated for in vitro antileishmanial activity against promastigotes of Leishmania donovani as per the standard protocol reported elsewhere. 2-(2,4-Dichlorophenoxy)-N′-{[4-(morpholin-4-yl)phenyl]methylidene}acetohydrazide (8k) showed the most promising antileishmanial activity with IC50 of 48.10 µM, free from cytotoxicity (>153.08 µM).
Related Topics
Physical Sciences and Engineering
Engineering
Engineering (General)
Authors
Mohamed Jawed Ahsan, Md Yousuf Ansari, Praveen Kumar, Monika Soni, Sabina Yasmin, Surender Singh Jadav, Ganesh Chandra Sahoo,