Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8206990 | Physics of Life Reviews | 2017 | 6 Pages |
Abstract
How do cells can sense the substrate stiffness? Our recent review highlighted a range of theoretical models and simulations that have been proposed to answer this important question. In response to this review, three leading groups in the field noted some important omissions not only from our review itself but also from the field. These groups noted, correctly, that much of our understanding of cellular mechanosensing arises from models that take advantage of equilibrium thermodynamics, and that this is inappropriate because living cells are never in thermodynamic equilibrium. In this response, we highlight some promising research aimed at resolving this conundrum.
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Physical Sciences and Engineering
Physics and Astronomy
Physics and Astronomy (General)
Authors
Bo Cheng, Min Lin, Guoyou Huang, Yuhui Li, Baohua Ji, Guy M. Genin, Vikram S. Deshpande, Tian Jian Lu, Feng Xu,