| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8208388 | Applied Radiation and Isotopes | 2018 | 24 Pages |
Abstract
Intercellular adhesion molecule-1(ICAM-1) is a potential molecular target and biomarker for triple negative breast cancer (TNBC) therapy and diagnosis. In this study, aICAM-1 was radioiodinated with 125I/131I in high radiochemical yield and the probes for TNBC tumor targeting and radioimmunotherapy were evaluated in tumor-bearing mice. High and specific accumulation of 125I-aICAM1 in TNBC MDA-MB-231 tumor was observed in SPECT imaging and the tumor grew was inhibited obviously by 131I-aICAM1. Thus, the radioiodinated aICAM1 could serve as potential agents for TNBC theranostics.
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Authors
Linyi You, Xiangyu Wang, Zhide Guo, Deliang Zhang, Pu Zhang, Jindian Li, Xinhui Su, Weimin Pan, Xianzhong Zhang,