Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8208410 | Applied Radiation and Isotopes | 2018 | 18 Pages |
Abstract
In this study, it is conjectured that this alternative production route will not replace the current supply chain based on the distribution of 99Mo/99mTc generators, but could become a convenient emergency source of Tc-99m only for in-house hospitals equipped with a conventional, low-energy, medical cyclotron. On this ground, an outline of the essential steps that should be implemented for setting up a hospital radiopharmacy aimed at the occasional production of Tc-99m by a small cyclotron is discussed. These include (1) target production, (2) irradiation conditions, (3) separation/purification procedures, (4) terminal sterilization, (5) quality control, and (6) Mo-100 recovery. To address these issues, a comprehensive technology for cyclotron-production of Tc-99m, developed at the Legnaro National Laboratories of the Italian National Institute of Nuclear Physics (LNL-INFN), will be used as a reference example.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Petra Martini, Alessandra Boschi, Gianfranco Cicoria, Federico Zagni, Andrea Corazza, Licia Uccelli, Micòl Pasquali, Gaia Pupillo, Mario Marengo, Massimo Loriggiola, Hanna Skliarova, Liliana Mou, Sara Cisternino, Sara Carturan, Laura Melendez-Alafort,